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After upgrading from App-V 5.0 Sp2 or App-V SP3 to App-V 5.1 , Internet explorer starts crashing for no reason. The Application event log shows two possible errors: 1.Faulting module : EMET.DLL 2.Faulting module : NTDLL.DLL This is a known bug with App-V 5.1. Some possible workaround is to either revert back to 5.0 or follow the below steps. Solution: Remove the following lines in the registry and IE 10 / IE 11 will stop crashing. HKEY_LOCAL_MACHINE / SOFTWARE / Microsoft / AppV / Client /Virtualization ProcessesUSingVirtualComponents Data: %ProgramFiles%\Internet Explorer\iexplorer.exe %ProgramFiles(x86)%\Internet Explorer\iexplorer.exe You can also try removing the App-V 5.0 earlier versions manually and then install App-V 5.1 instead of upgrading to avoid this issue. Though the above said step is just a workaround, it is not a recommended way to bypass this issue. We need to wait for Microsoft to come up with possible fix or service pack soon. Technet post - https://social.technet.m...

After upgrading App-V 5.0 Management and Publishing servers to App-V 5.1, you may encounter a problem where publishing no longer function properly and the following issues appear: - Accessing the Publishing URL in Internet Explorer from directly on the Publishing Server (e.g.http://localhost:82, where 82 is the port assigned to the Publishing Server Service) generates the following error message: The website cannot display the page - The event below is seen in Event Viewer\Applications and Servers logs\App-V\Server-Publishing-Private\Debug: Failed to pre-load publishing metadata.  Message: Object reference not set to an instance of an object.  Details:   Stack Trace:     at Microsoft.AppV.Server.Publishing.PublishingMetadataSerializer.PackageSerializer.Load(XElement pkgElement, PublishingMetadata& data)     at Microsoft.AppV.Server.Publishing.PublishingMetadataSerializer.RootSerializer.Load(XmlReader reader)     at Microsof...

Check out  Simon Dettling  post about how to upgrade your App-V management server to 5.1 in easy steps. http://msitproblog.com/2015/10/18/upgrade-your-app-v-management-server-to-5-1/ Also check Microsoft Technet link. http://blogs.technet.com/b/appv/archive/2015/09/23/a-simplified-microsoft-app-v-5-1-management-server-upgrade-procedure.aspx

Check this official Microsoft Technet Link to know more about how to upgrade App-V 5.1 Management Server http://blogs.technet.com/b/appv/archive/2015/09/23/a-simplified-microsoft-app-v-5-1-management-server-upgrade-procedure.aspx